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Koronavirüse yakalananların yoğun bakım a ihtiyaç duyma veya ölme ihtimalini ortaya koyabilecek yeni bir kan testi geliştirildi. Semptom göstermeye başladıktan kısa bir süre sonra yapılması planlanan bu test şu anda hastanelerde deneniyor. Hastanelerdeki deneyler, testin doğruluk oranını ölçecek.
TEST SONUCU SONRASINDA KARAR VERİLECEK Guardian gazetesinin haberine göre doktorlar bu test sayesinde yoğun bakım a ihtiyaç duyacak hastaları tespit edip onlara önceden daha fazla destek vererek hayatta kalma şanslarını artırabilir.
Doktorlar hastane kapasitesinin dolmaya yaklaştığı durumlarda palyatif bakım veya yoğun bakım ünitesine hasta kabul etme konusundaki zor kararları da bu test sonucuna göre daha rahat bir şekilde verebilir.
27 AYRI PROTEİN TÜRÜNÜ İNCELİYOR Bilim insanı Markus Ralser'in ekibiyle geliştirdiği testte Covid-19 hastalarının kanlarındaki 27 ayrı protein türünün miktarı inceleniyor.
Bugüne kadar 160 hastanın durumunu inceleyen ve protein oranlarıyla ölüm oranı ve yoğun bakım a ihtiyaç duyma oranlarını inceleyen ekip, hangi proteinin ne seviyede bulunduğuna bakarak bu oranların anlaşılabileceğini ortaya koydu.
KOLAYLIK SAĞLAYACAK Böylece doktorlar, bir hastanın dış görünüşünden anlayamasa bile test yaparak hastalığı ne kadar ciddi geçirebileceğini anlayabilecek.
O DOKTOR ANLATTI Guardian'a konuşan Londra 'daki Francis Crick Enstitüsü'nden Prof. Ralser, bazı Covid-19 hastalarında "mutlu hipoksi" denen bir olgunun görüldüğünü, genel olarak iyi durumdaki bu hastaların ansızın kötüleşebildiğini anlatıyor ve ekliyor:
"Bu tür hastaların Covid-19'a karşı erken bir yangın tepkisi verdiğini anladık. Bu tepkinin ürettiği proteinlerin kandaki miktarını ölçerek hastaya '40 gün sonra şu halde olma ihtimalin bu kadar' diyebileceğiz.
"Covid-19'da ilk günler çok önemli. Yoğun bakım a ihtiyaç duyacak kişileri ne kadar erken yoğun bakıma alırsak hayatta kalma şansları o kadar artıyor."
Guardian'a göre hastaların yoğun bakıma geçirilip geçirilmeyeceği konusundaki karar sadece bu test üzerinden alınmayacak olsa da test sonucu doktorların kararında önemli bir etken olabilir.
5 HASTANIN TAMAMINI DOĞRU TAHMİN ETTİ Şu ana kadar 24 hasta üzerinde kontrol deneyi süren test, hayatını kaybeden beş hastanın tamamını doğru tahmin etti.
Hayatta kalmayı başaran 19 hastadan da 18'i doğru tahmin edildi.
NASIL TESPİT EDİYOR? Araştırmasının taslak hali yayınlanan fakat henüz diğer bilim insanlarının denetiminden geçmemiş olan Ralser, "Hangi hastanın oksijen veya solunum cihazı desteğine ihtiyaç duyabileceğini epey başarılı bir şekilde tespit edebiliyoruz. Benzer bir şekilde, başlangıçta durumu kötü olmayanlar arasından da hızla kötüleşme ihtimali olanları başarıyla tespit edebiliyoruz" dedi.
Deneyin bir sonraki aşamasında test Almanya , İngiltere ve ABD'deki 10 hastanede denenecek.
'YENİ TEDAVİ YÖNTEMLERİYLE DE DENENMESİ LAZIM' Önümüzdeki haftalarda başlaması beklenen son deneyin ardından veriler sağlık alanındaki düzenleyici kurumlarla paylaşılacak ve her şey yolunda giderse deney daha yaygın bir şekilde erişilebilir olacak.
Araştırmayı dışardan değerlendiren British Hearth Foundation (Britanya Kalp Vakfı) profesörü Manuel Mayr bunun önemli bulgular verebileceğini söylüyor. Fakat Mayr'ın bir uyarısı da var:
"Bu araştırmada örnekler pandeminin başında toplanmıştı. O zamanlar hastalar bağışıklık sistemi tepkisini baskılayan dexamethasone gibi ilaçlar almıyordu.
"Bu ilaç artık ciddi Covid-19 vakalarında stadart bir şekilde uygulanır oldu. Bu yüzden en güncel tedaviyi alan hasta gruplarından örnekler alınarak protein seviyelerinin baştan incelenmesi gerekir."
AYNI TEKNİK 'BAŞKA ALANLARDA DA KULLANILABİLİR' Mayr kendilerinin de benzer bir test geliştirmekte olduklarını, o testte proteinlerin yanı sıra kandaki virüs RNA'sı oranını da inceleyerek bir sonuca vardıklarını söyledi.
Guardian'ın serbest bilim muhabiri Linda Geddes, proteom (bir organizma veya sistem tarafından üretilen veya modifiye edilen proteinlerin tamamı) temelli bu testler onaylanana kadar koronavirüs pandemisinin hafiflemiş olabileceğini fakat aynı tekniklerin kanser, diyabet ve Alzheimer gibi beyindeki ilerleyen nöron kaybıyla ilgili hastalıklarda işe yarayabileceğini söylüyor.